The pharmacokinetic process namely absorption, distribution, metabolism, and excretion of the drug may be affected due to the food-drug interaction. It’s important to study because at smaller or wider levels the lack of knowledge of food-drug interaction affects the pharmacokinetics and pharmacodynamics which gives rise to potential adverse effects or altered therapeutic outcomes. To avoid this type of complication healthcare professionals need to provide basic food-drug interaction knowledge about prescribed drugs to the patient to minimize the risk and improve the drug effects for faster recovery. To increase patient safety it’s necessary to highlight the commonly prescribed drugs (such as Amoxicillin, Omeprazole, Cephalexin, Atorvastatin, Vitamin D) and food-drug interaction. This review provides information about various commonly prescribed food-drug interactions and it will help healthcare professionals in prescribing drugs cautiously with an appropriate diet to avoid complications.