Even though the liver has many receptors, hepatic disorders are becoming one of the rare conditions that cannot be successfully healed for several reasons. Nowadays, a lot of passive targeted delivery methods are used to deliver drugs or genes to treat disorders of interior organs. More importantly, by interacting with target receptors and orienting ligands, entirely different actions would be taken in tandem with the desired cell that was damaged or dysfunctioned. This would improve the accumulation of medication within the target cell and reduce nonspecific toxicity towards other cells or organs. Millions of people worldwide suffer from severe liver illnesses that are incurable despite numerous attempts, necessitating the search for novel therapeutic approaches. Strong medications may not work well enough in vivo or may have negative side effects; this could be significantly improved by increasing distribution into the target cells. Our goal is to provide an overview of the available options for medication administration to the different intrahepatic cell types.